I recently came across
HHpred (described in
Soding et al 2005), a program for looking for remote homologues by using HMMs. A nice use case of this is in the paper by
Valentim et al 2013, where they used HHpred to predict that the
Schistosoma mansoni protein that is involved in response to the drug oxamniquine has structural similarity to sulfotransferases.
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